2026 MLB: Twins vs. Nationals Picks and Prediction for Thursday, May 7

Twins vs. Nationals prediction, odds, time: 2026 MLB picks for Thursday, May 7 from proven model

SportsLine's model simulated Minnesota Twins vs. Washington Nationals 10,000 times and revealed its MLB picks for Thursday's matchup

By Andy Bryan

May 7, 2026 at 10:14 am ET • 2 min read

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The Minnesota Twins will look to win the series on the road when they face off against the Washington Nationals in the third and final game of the series on Thursday afternoon. The series is tied 1-1, with Washington coming off a 15-2 win on Wednesday. The Twins (16-21), who have lost three of five, are 6-11 on the road this season. The Nationals (17-20), who have two of their last three, are 5-13 on their home field in 2026.

First pitch from Nationals Park in Washington, D.C., is set for 1:05 p.m. ET. The Nationals lead the all-time series 15-14, and are 7-8 all-time at home against the Twins. Washington is a -116 favorite on the money line (risk $116 to win $100) in the latest Nationals vs. Twins odds, while the over/under, is 9. Before making any Nationals vs. Twins picks, be sure to see the Twins vs. Nationals predictions and betting advice from SportsLine's proven computer model .

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The SportsLine Projection Model simulates every MLB game 10,000 times, and is coming off a 5-0 week on top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following its  MLB betting  picks at  sportsbooks  and on  betting sites  could have seen strong returns.

Now, the model has set its sights on Twins vs. Nationals and just locked in its picks and MLB predictions.  You can head to SportsLine now to see the model's picks . Here are several  MLB odds  and betting lines for Nationals vs. Twins:

Twins vs. Nationals money line

Nationals -116, Twins -102

Twins vs. Nationals over/under

9 runs

Twins vs. Nationals run line

Nationals +1.5 (-183)

Twins vs. Nationals picks

See picks at SportsLine

Twins vs. Nationals streaming

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Top Twins vs. Nationals predictions

After 10,000 simulations of Twins vs. Nationals, the model is going Over 9 combined runs. For over/under betting , the Over has hit in the first two games of the series for these two teams. The Over has hit in four of the last five games for the Minnesota Twins. The total has gone Over in five of the Nationals' last six games at home against the Twins.

SportsLine's model projects 1.48 total bases or more for the Twins Byron Buxton , Luke Keaschall , Ryan Jeffers , and Royce Lewis . The Nationals, meanwhile, are projected to get over 1.7 total bases from James Wood and CJ Abrams . The model projects 9.7 combined runs as the Over hits in 51.7% of simulations. Get the Twins vs. Nationals money-line pick at SportsLine .

How to make Nationals vs. Twins picks

After simulating every pitch of Twins vs. Nationals 10,000 times, the model also says one side of the money line has all the value. You can get that pick at SportsLine .

So who wins Nationals vs. Twins, and which side of the money line has all the value?  Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks , and find out.

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_Originally reported by [CBS Sports](https://www.cbssports.com/mlb/news/twins-nationals-prediction-odds-time-2026-mlb-picks-thursday-may-7/)._