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The Kansas City Chiefs look to rebound from a rare non-playoff year when they kick off the 2026 season against the defending AFC West champion Denver Broncos on Monday Night Football. After winning the AFC West for nine consecutive seasons and reaching the Super Bowl in five of six seasons, Kansas City slumped to 6-11 in 2025. Denver, meanwhile, was 14-3 last season and earned its first division title since 2015. The Broncos reached the AFC Championship Game where they dropped a 10-7 decision to the New England Patriots .  New to sports trading? Visit our  Kalshi promo code  review and  get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS :

Kickoff is at 8:15 p.m. ET from Arrowhead Stadium in Kansas City, Mo. The latest Broncos vs. Chiefs odds have Kansas City as 2.5-point favorites, while the over/under for total points scored is 43.5 via SportsLine consensus. Before making any Broncos vs. Chiefs picks, be sure to  see the NFL predictions from SportsLine's projection model .

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on  betting sites  on top-rated  NFL picks  since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at  NFL betting sites  could have seen strong returns.

Now, the model has zeroed in on Broncos vs. Chiefs . You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Chiefs vs. Broncos:

Broncos vs. Chiefs spread

Chiefs -2.5 at DraftKings Sportsbook

Broncos vs. Chiefs over/under

43.5 points

Broncos vs. Chiefs money line

Broncos +129, Chiefs -153

Broncos vs. Chiefs picks

See picks at SportsLine

Broncos vs. Chiefs streaming

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Top Broncos vs. Chiefs predictions

After 10,000 simulations of Chiefs vs. Broncos, the model is  going Under 43.5 combined points at  betting apps . The Broncos had one of the best defenses in the league last year, holding opponents to just 18.3 points per game, third-least in the NFL. Kansas City was also solid, allowing 19.3 points, which was No. 6.

Denver quarterback Bo Nix is projected to be held to under 200 yards passing with just one touchdown. Kansas City's Patrick Mahomes , meanwhile, is projected to throw for 180 yards and one score. SportsLine's model projects 40 combined points between the Broncos vs. Chiefs.  See which team to back at SportsLine .

How to make Broncos vs. Chiefs picks

For Broncos vs. Chiefs on Monday Night Football for Week 1, the model is leaning Under the total, projecting 39 combined points. It also says one side of the spread hits over 50% of the time.   See what it is at SportsLine .

Who wins Broncos vs. Chiefs, and which side of the spread hits in over 50% of simulations?  Visit SportsLine now to see which side of the Broncos vs. Chiefs spread you need to jump, all from the model that is 53-37 on top-rated picks since 2024 , and find out.

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_Originally reported by [CBS Sports](https://www.cbssports.com/betting/news/chiefs-broncos-prediction-odds-time-nfl-week-1-picks-best-bets-monday-night-football/)._