50 Cent Playfully Reacts to Cardi B Disliking His Track '21 Questions' at Club

50 Cent playfully responded to Cardi B not feeling his Get Rich or Die Tryin’ single “21 Questions” during a recent nightclub appearance.

The G-Unit boss reposted a clip Monday (Sept. 28) of Cardi providing ad-libs while “21 Questions” played, which saw her seemingly sending shots at her exes Stefon Diggs and Offset.

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On the 2003 Billboard Hot 100 No. 1 smash, 50 peppers his love interest with questions about her commitment and devotion to him, no matter what obstacles life throws his way, even if times get rough. Cardi chimed in, repeating “hell no” as she responded to 50’s bars.

The Queens legend didn’t take any offense to Cardi, and in true 50 fashion, fanned the flame while subliminally calling out the “WAP” rapper’s famous exes.

“Cardi said Nope, she not with none of that s–t after her last 2 🥷🏾 LOL she out here killing shit,” Fif wrote on Instagram.

“Hell No!!!… That’s a response from experience,” one fan wrote in his comments. Another added: “Cardi needs to make a song called 21 answers.”

Cardi B filed for divorce from Offset for a second time in August 2024; he is the father of her first three children. The “WAP” rapper moved on to NFL star Stefon Diggs in early 2025 and welcomed a baby boy together in November. However, the couple appeared to split in the first quarter of 2026.

On the music front, Cardi B released her “AH HA” single in July, which debuted at No. 25 on the Hot 100. The 33-year-old also revealed that she’s working on a new album set for 2027.

_Originally reported by [Billboard](https://www.billboard.com/music/rb-hip-hop/50-cent-responds-cardi-b-21-questions-1236349143/)._