Expert's Sunday Night Football Picks: Colts vs. Chiefs Week 2

After looking like the team that won three Super Bowls this past decade, the Kansas City Chiefs look to continue that momentum when they battle the Indianapolis Colts on Sunday Night Football. Kansas City opened the season with a 31-10 thrashing of the Denver Broncos on Monday night, while Indianapolis dropped a 41-23 decision to the Baltimore Ravens on Sunday. The Colts (0-1), who have lost eight consecutive games dating back to last season, are 2-6 on the road since last September. The Chiefs (1-0), who have made the postseason in 10 of the last 11 seasons, are 6-4 on their home field since the start of 2025. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades :

Kickoff is at 8:20 p.m. ET from GEHA Field at Arrowhead Stadium in Kansas City, Mo. The latest Colts vs. Chiefs odds have Kansas City as a 6.5-point favorite, while the over/under for total points scored is 46.5. The Chiefs are at -306 on the money line (risk $306 to win $100). Indy is 8-8-2 against the spread since the start of last season, with Kansas City at 7-10-1 ATS. Before making any Colts vs. Chiefs picks, be sure to  see what R.J. White has to say .

CBS Sports' managing editor of Fantasy and gambling, White twice has cashed huge in the world's most prestigious handicapping tournament, the Westgate Las Vegas SuperContest. Over the past 11 years, his Vegas contest picks are 508-424-28 (54.5 percent). White consistently crushes the NFL : He went 803-705-41 on ATS picks from 2017-25, returning more than $2,700 to $100 players as SportsLine's No. 1 NFL expert in against the spread picks on NFL betting sites . He enters this season on a 31-19-3 roll on picks involving the Colts, returning $1,004 to $100 players. Anyone following his picks on betting sites could have seen huge returns.

Now, White has zeroed in on Colts vs. Chiefs . You can head to SportsLine now to see his picks. Here are several NFL odds and betting lines for Chiefs vs. Colts:

Colts vs. Chiefs spread

Chiefs -6.5

Colts vs. Chiefs over/under

46.5 points

Colts vs. Chiefs money line

Chiefs -306, Colts +248

Colts vs. Chiefs picks

See picks at SportsLine

Colts vs. Chiefs streaming

Fubo  (Try for free)

New to sports trading? Visit our  Kalshi promo code  review and  get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS :

Top Colts vs. Chiefs predictions

White is leaning Under 46.5 combined points for   over/under betting  at  betting apps . Both Patrick Mahomes (ACL, MCL) of the Chiefs and Daniel Jones (Achilles) of the Colts are coming back from injury and have been slowed a bit early on. Mahomes did throw two touchdown passes and ran for another score on Monday against the Broncos. He threw for a modest 184 yards.

Jones, meanwhile, was held to 166 yards passing with one touchdown and one interception in the loss to Baltimore. The Under has hit in eight of the last 10 head-to-head matchups between the Colts and Chiefs. The Under has also hit in nine of the past 10 Kansas City games, including each of the last six.  See which team to back at SportsLine .

How to make Colts vs. Chiefs picks

White also has found a crucial X-factor that makes one side of the spread a must-back.   See what it is at SportsLine .

Who wins Colts vs. Chiefs on Sunday Night Football, and what X-factor makes one side of the spread hit hard?  Visit SportsLine now to see which side of the Colts vs. Chiefs spread you need to jump, all from the expert who has returned $1,004 to $100 players over his last 53 Indianapolis picks , and find out.

Add CBS Sports on Google Join the Conversation comments

_Originally reported by [CBS Sports](https://www.cbssports.com/betting/news/sunday-night-football-prediction-odds-time-colts-chiefs-picks-best-bets/)._