Giants vs. Rams: NFL Week 2 Monday Night Football Predictions from SportsLine Model

The New York Giants will look to continue their strong start to the season when they take on the Los Angeles Rams on 'Monday Night Football.' New York is coming off a 28-20 win over the Dallas Cowboys, while Los Angeles dropped a 27-7 decision to the San Francisco 49ers in Melbourne, Australia. The Giants (1-0), who finished fourth in the NFC East at 4-13, were 1-8 on the road in 2025. The Rams (0-1), who tied for second in the NFC West at 12-5, are 7-2 as the home team since the beginning of last season. Puka Nacua (hip) is questionable for L.A.  Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades :

Kickoff is set for 8:15 p.m. ET from SoFi Stadium in Inglewood, Calif. The latest Giants vs. Rams odds have Los Angeles as 7-point favorites, while the over/under for total points scored is 47.5. The Rams are at -353 on the money line (risk $353 to win $100). Before making any Giants vs. Rams picks or 2026 NFL Week 2 predictions, be sure to  see what the SportsLine projection model has to say .

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on  betting sites  on top-rated NFL picks since its inception. The model enters Week 2 of the 2026 NFL season on a 53-39 run on top-rated picks dating back to 2024. Anybody following its picks at  NFL betting sites  could have seen strong returns.

Now, the model has zoned in on Giants vs. Rams . You can head to SportsLine now to see its picks . Here are several NFL odds and betting lines for Rams vs. Giants:

Giants vs. Rams spread

Los Angeles Rams -7

Giants vs. Rams over/under

47.5 points

Giants vs. Rams money line

Los Angeles Rams -353, New York Giants +281

Giants vs. Rams picks

See picks at SportsLine

Giants vs. Rams streaming

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Top Giants vs. Rams predictions

After 10,000 simulations of Giants vs. Rams, the model is  going Over 47.5 points at betting apps . The Over has hit in five of the last eight head-to-head meetings between the Giants and Rams, including one push. The Over hit in their last meeting, a 26-25 Rams win on Dec. 31, 2023. The Over has also hit in eight of the last 10 New York games and eight of the last 10 Los Angeles games.

Giants quarterback Jaxson Dart is coming off a solid season opener, which saw him complete 23 of 29 passes for 230 yards and three touchdowns. Running back Cam Skattebo added 81 yards rushing and one touchdown on 18 carries. Despite a slow start to his season, Rams quarterback Matthew Stafford is coming off an MVP season. In 17 games, he threw for 4,707 yards and 46 touchdowns with eight interceptions. The model projects 52 combined points, giving value to the Over in 54% of simulations.  See which team to back at SportsLine .

How to make 'Monday Night Football' picks

In addition to going Over, the model also says one side of the spread is hitting in well over 50% of simulations. See what it is at SportsLine .

Who covers in Giants vs. Rams, and which side of the spread has all the value? Visit SportsLine now to see which side of the Giants vs. Rams spread you need to jump, all from the model that's on a 53-39 run on top-rated picks since 2024 , and find out.

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_Originally reported by [CBS Sports](https://www.cbssports.com/betting/news/giants-rams-predictions-odds-time-nfl-week-2-monday-night-football-picks-best-bets/)._