SportsLine Model

Three Top 25 matchups highlight the Week 5 college football schedule, with two of them coming in the SEC. No. 7 Alabama takes on No. 16 Mississippi State in what should be a fascinating test at home for quarterback Kamario Taylor and the upstart Bulldogs. No. 8 Florida, meanwhile, is coming off back-to-back SEC wins under first-year coach Jon Sumrall, and now the Gators go on the road to take on No. 25 Missouri. The latest Week 5 college football odds list the Crimson Tide at -6, while the Gators are -4.5  Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades :

The Big Ten slate, meanwhile, is highlighted by No. 5 Ohio State heading to No. 14 Iowa, who just knocked off Michigan, in a matchup on CBS and Paramount+ . Ohio State is -14 in that one. Before locking in any Week 5 college football picks on those games or others, be sure to see the latest college football score predictions from SportsLine's proven model .

The model simulates every FBS game 10,000 times. It enters Week 5 on a 32-24 run on all top-rated college football picks at  betting sites , returning nearly $600 for $100 players. Anybody following its picks on college football betting sites could have seen strong returns.

Now, it has turned its attention to the latest college football odds for Week 5 and locked in picks for every FBS matchup.  Head here to see every pick .

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Top college football score predictions for Week 5

One college football score prediction for the Week 5 college football schedule at the best betting apps : The model is projecting Texas A&M to beat Arkansas 31-14 . That makes Texas A&M (-14) the play against the spread in 54% of simulations, while the Under (51.5) hits 63% of the time.

It's been a tough start to SEC play for Texas A&M as the Aggies were stunned by Kentucky at home and then got blown out at LSU. The model, however, sees this as a bounce-back spot for A&M against what might be the worst team in the SEC.

Arkansas has lost by at least 28 points and has failed to cover in both matchups against Power 4 opponents.  See the model's score predictions for every other matchup here .

College football best bets for Week 5

The model has also made the call on the exact score prediction for each Week 5 college football game, including backing multiple underdogs to win outright.  You can only get every pick for every game at SportsLine .

So what is the exact projected score for each game, and which underdogs pull off a shocking upset? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that is on a 32-24 run , and find out.

College football lines for notable Week 5 games

See full Week 5 college football picks, odds, predictions here . Odds via FanDuel and subject to change

Thursday, Oct. 1 Western Kentucky at New Mexico State (-1.5, 53.5) North Texas at Tulsa (-2.5, 57.5)

Friday, Oct. 2 Liberty at Delaware (+7, 49.5) Pittsburgh at Virginia Tech (-3.5, 52.5) Penn State at Northwestern (+2.5, 45.5)

Saturday Oct. 3 Alabama at Mississippi State (+6, 59.5) Navy at Air Force (-2.5, 47.5) Notre Dame at North Carolina (+21.5, 47.5) Auburn at Tennessee (-7.5, 54.5) Florida at Missouri (+4.5, 56.5) Ohio State at Iowa (+13.5, 45.5) Miami at Clemson (+17.5, 49.5) Texas Tech at Colorado (+13.5, 50.5) Washington at USC (-9.5, 56.5)

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_Originally reported by [CBS Sports](https://www.cbssports.com/betting/news/college-football-score-predictions-picks-for-week-5-2026/)._