Tom Cruise, Conan O'Brien, Queen Latifah Set for The Tonight Show Starring Jimmy Fallon

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Tom Cruise, Sandra Bullock, Conan O'Brien and John Cusack lead the week's guest roster.

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NBC has issued a new round of guest listings for THE TONIGHT SHOW STARRING Jimmy Fallon , detailing a run of episodes set to feature Tom Cruise , Lili Reinhart , Sandra Bullock , Mike D, Queen Latifah , Dave Franco , Conan O'Brien , Brandon Flowers , Lauren Lapkus, John Cusack , Cara Delevingne , Chef Daniel Humm, Karl-Anthony Towns, Sienna Miller and Stefano Domenicali. Musical performances across the episodes are set to come from Suki Waterhouse, Mike D 5D, Brandon Flowers and Cara Delevingne .

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Thursday, September 17: Guests include Tom Cruise , Lili Reinhart and musical guest Suki Waterhouse. Show #2342

Friday, September 18: Guests include Sandra Bullock , Mike D and musical guest Mike D 5D. (OAD 9/8/26)

Monday, September 21: Guests include Queen Latifah , Dave Franco and comedian Ethan Simmons-Patterson. Show #2343

Tuesday, September 22: Guests include Conan O'Brien , Brandon Flowers , Lauren Lapkus and musical guest Brandon Flowers . Show #2344

Wednesday, September 23: Guests include John Cusack , Cara Delevingne , Chef Daniel Humm and musical guest Cara Delevingne . Show #2345

**Thursday, September 24: Guests include Karl-Anthony Towns, Sienna Miller , Stefano Domenicali and comedian Gary Simons. Show #2346

**denotes changes or additions

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_Originally reported by [BroadwayWorld](https://www.broadwayworld.com/bwwtv/article/THE-TONIGHT-SHOW-STARRING-Jimmy-Fallon-to-Welcome-Tom-Cruise-Conan-OBrien-20260917)._