Week 4 NFL: Odds, Betting Lines, Spreads, and Totals for All Games

It's another loaded slate for NFL betting, with matchups like Cowboys vs. Texans, Rams vs. Eagles, Chiefs vs. Raiders and Lions vs. Panthers on tap. According to the latest Week 4 NFL odds, the Cowboys are 2.5-point underdogs against Houston, despite the Texans entering Sunday's showdown with a 0-3 record. Other notable Week 4 NFL lines include Rams vs. Eagles (+3), Chiefs vs. Raiders (+4.5) and Lions vs. Panthers (+3.5). Bet on every Week 4 NFL game with the latest DraftKings promo code, where new users get $150 in bonus bets after making a $5 wager :

Below you'll find the NFL betting odds for every Week 4 matchup. You can find the SportsLine Projection Model's NFL betting advice for Week 4  here .  Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get $55 as a sign-up bonus:

** Odds provided by DraftKings are subject to change **

Sunday, Oct. 4

Indianapolis Colts vs. Washington Commanders

Spread: Colts -3.5 Moneyline: Colts (-187), Commanders (+155) Total: 47

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New England Patriots vs. Buffalo Bills

Spread: Bills -6.5 Moneyline:  Bills (-324), Patriots (+258) Total: 48.5

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Tennessee Titans vs. Baltimore Ravens

Spread:  Ravens -11.5 Moneyline:  Ravens (-714), Titans (+509) Total:  43.5

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New York Jets vs. Chicago Bears

Spread: Bears -3 Moneyline:  Bears (-156), Jets (+132) Total: 43

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Jacksonville Jaguars vs. Cincinnati Bengals

Spread: Bengals -2.5 Moneyline:  Bengals (-142), Jaguars (+120) Total:  51.5

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Dallas Cowboys vs. Houston Texans

Spread:  Texans -2.5 Moneyline:  Texans (-140), Cowboys (+119) Total: 47.5

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Arizona Cardinals vs. New York Giants

Spread:  Cardinals -1 Moneyline:  Cardinals (-112), Giants (-106) Total: 44.5

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Los Angeles Rams vs. Philadelphia Eagles

Spread:  Rams -3 Moneyline:  Rams (-162), Eagles (+136) Total:  44

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Green Bay Packers vs. Tampa Bay Buccaneers

Spread:  Packers -4 Moneyline:  Packers (-188), Buccaneers (+157) Total:  39.5

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Miami Dolphins vs. Minnesota Vikings

Spread:  Vikings -10.5 Moneyline:  Vikings (-637), Dolphins (+469) Total:  38.5

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Kansas City Chiefs vs. Las Vegas Raiders

Spread:  Chiefs -4.5 Moneyline:  Chiefs (-222), Raiders (+184) Total: 47.5

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Denver Broncos vs. San Francisco 49ers

Spread:  49ers -2.5 Moneyline:  49ers (-149), Broncos (+125) Total: 46.5

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Los Angeles Chargers vs. Seattle Seahawks

Spread:  Seahawks -7 Moneyline:  Seahawks (-334), Chargers (+268) Total:  43

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Detroit Lions vs. Carolina Panthers

Spread:  Lions -3.5 Moneyline:  Lions (-193), Panthers (+163) Total:  50.5

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Monday, Oct. 5 Atlanta Falcons vs. New Orleans Saints

Spread:  Saints -2.5 Moneyline: Saints (-151), Falcons (+127) Total: 48.5

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_Originally reported by [CBS Sports](https://www.cbssports.com/betting/news/week-4-nfl-odds-betting-lines-totals-spreads/)._